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KMID : 1094020150320010062
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Journal of Veterinary Clinics
2015 Volume.32 No. 1 p.62 ~ p.68
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A Specific Biomarker for The Diagnosis of Equine Laminitis Seungwoo
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Lee Seung-Woo
Lee Seung-Heon
Kim Myung-Chul
Kim Yong-Baek
Ryu Doug-Young
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Abstract
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There is no reliable indicator available for the diagnosis of horse laminitis, although the disease is commonand costly. This study was performed to develop a specific diagnostic biomarker for laminitis. We have identified33 differentially expressed proteins in plasma of a horse suffering laminitis that is experimentally induced by an overdoseof oligofructose, in comparison with normal horse plasma. Among the proteins, myosin-9 mRNA was found in RNAsequencing analysis to be expressed specifically in laminitis tissues compared to other horse tissues. It is thus suggestedthat expression of plasma myosin-9 may be used for the diagnosis of equine laminitis.
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KEYWORD
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equine laminitis, diagnosis, mass spectrometry, next generation sequencing, myosin-9, biomarker
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